The connection between the gallbladder and SIBO is due to the antimicrobial properites of bile that helps to keep the terrain of the small intestine clean. Having enough bile prevents bacteria from the colon from colonizing the small intestine. Bile is your body’s natural defense to prevent SIBO. While there can be other underlying root causes of SIBO, having a sluggish gallbladder and low bile flow is one reason someone can develop SIBO symptoms. ~ Didem