Symptoms of poor methylation include histamine intolerance and all the symptoms associated with histamine intolerance. But what is the connection between poor methylation, MTHFR and histamine intolerance?The MTHFR gene mutation is 1 of the common SNP’s in the methylation pathway among others that can decrease the ability of the body to produce SAMe to help with the metabolism of histamine. #mthfr #genetics #histamineintolerance ~ Didem