There is a strong connection between the MTHFR gene mutation, PEMT gene, and small intestine bacterial overgrowth, especially when bile flow has been disrupted. The PEMT gene relies heavily on SAMe from the methylation cycle to produce phosphatidylcholine, and when this process slows down, bile can become thick and sluggish. Because bile is naturally supportive to microbial balance in the small intestine, reduced bile flow may contribute to irritable bowel and small intestine bacterial overgrowth. This is where a nutrigenomics nutrition approach offers clarity and direction. Instead of focusing on restriction, it highlights how to nourish your body based on your unique genetics. ~ Didem