Not all probiotics are beneficial for people with SIBO, but L reuteri is one of the best probiotics for SIBO as it produces an antimicrobial compound that inhibits the growth of bacteria in the small intestine. Many People with SIBO do not tolerate broad-spectrum probiotics. They may even experience a worsening of SIBO symptoms, but l reuteri is among the best probiotics for SIBO. ~ Didem