The MTHFR gene is a key enzyme in the methylation pathway involved in the production of the methyl donor SAMe that is required to make phosphatidylcholine via the PEMT gene. When this process is impaired due to an MTHFR or PEMT mutation, the body struggles to produce phosphatidylcholine, a compound necessary for moving fat out of the liver. This leads to fat accumulation and insulin resistance in the liver, making fat loss more challenging. Insulin resistance also prevents the body from breaking down stored fat efficiently, keeping free fatty acids circulating and contributing to stubborn belly fat. Supporting methylation with key nutrients like folate, vitamin B2, B12, magnesium, and choline can improve fat metabolism and aid in losing weight. Fat loss diet, fat loss tips. ~ Didem