Having SNP In the MTHFR gene or the methylation pathway can contribute to SIBO. But what is the connection between poor methylation, a sluggish gallbladder, MTHFR and SIBO? If you have MTHFR and SIBO then you need to understand the link between an MTHFR gene mutation and gallbladder function as optimizing methylation and improving bile flow is crucial for preventing SIBO and getting rid of SIBO symptoms ~ Didem