A person needs to have a functioning MTHFR gene and Methylation cycle so that a methyl donor called SAMe (s-adenosylmethionine) is produced in sufficient quantities. The methyl donor SAMe is required to make phosphatidylcholine which is key for keeping the bile flowing smoothly out of the gallbladder.Having a gallbladder that functions well, allowing the bile to flow smoothly when needed is crucial to prevent SIBO overgrowth as bile is ANTIMICROBIAL. #sibo #mthfr #guthealth ~ Didem